USAMRIID

The U.S. Army Medical Research Institute of Infectious Diseases at Fort Detrick.

A new study out of the U.S. Army Medical Research Institute of Infectious Diseases offered insight on how filoviruses, a group of viruses that cause hemorrhagic fever in humans, might persist.

The researchers at USAMRIID, at Fort Detrick, found persistent Marburg virus, a deadly type of filovirus that can infect humans, in other primates. More specifically, they found it in the testes of crab-eating macaques, according to the article published in Cell Host and Microbe.

USAMRIID scientists studied brain, eye, liver, lymph node, spleen and testes tissue from 97 macaques that had previously survived Marburg. They found the disease persisted in the testes, even after it had cleared the other target organs, such as the brain or liver.

The researchers knew the disease persisted, but the study showed some of the mechanisms of how the disease remained in the testes, said Dr. Travis Warren, one the authors of the paper and a principal investigator at USAMRIID.

“That’s a novel and new finding to the field,” Warren said.

Of the 73 male monkey survivors, 22 had MARV genomic RNA in their testes. Evidence of the disease was not found in the brains of the monkeys. Marburg virus damages the testes, leading to breakdown of the blood-testes-barrier that protects Sertoli cells, which help nourish sperm production.

With the barrier broken, the Sertoli cells are likely where Marburg is stored, at least in crab-eating macaques.

While the researchers said in the study that they believed the disease would clear the testes, more testing would be necessary to understand how frequently it would be cleared. While the Sertoli cells were affected, the disease does not seem to affect overall reproductive function, including sperm generation.

While Marburg is a different disease than Ebola, they are both filoviruses, and the research conducted at USAMRIID may shed light on ways Ebola persists as well, according to the study. The findings might indicate why human survivors of Ebola have Ebola RNA in their semen despite having no clinical signs of the disease, the authors wrote.

And although the study used crab-eating macaques, there could be some implications for humans, said Kevin Zeng, senior molecular scientist at USAMRIID. The findings could help lead to a test for filovirus persistence, he said.

It opens up new possibilities for therapeutic and counter measures, Warren said. Because of the ability of filoviruses to persist and re-emerge, it is important that researchers keep studying the disease, said Jun Liu, author of the paper and researcher at USAMRIID.

“It is important for us to keep researching the mechanisms of this virus,” Liu said.

Studying filoviruses is a part of USAMRIID’s public health mission, and it is important to keep studying the diseases in order to find better preventive and therapeutic measures, Warren said.

The scientists said they will continue to research filoviruses, including establishing an animal model that will better represent filoviruses in humans, Liu said.

Filoviruses are extremely infectious and are frequently fatal, according to the study.

“Therefore, a single case of filovirus persistence in a survivor of filovirus disease could pose a high risk for new outbreaks and considerable loss of lives,” according to the study.

Follow Heather Mongilio on Twitter: @HMongilio.

Recommended for you

(15) comments

sej58

JW hate to break it to you but computers are not living organisms.

Samanthapowers

Junk scientists ‘practicing’ junk science. They’re fossils.

sej58

You know nothing about what you speak.

gabrielshorn2013

Here is a link to the original report for those that are interested:

Mechanism of Marburg virus sexual transmission identified in nonhuman primates
New research elucidates the mechanism of sexual transmission of filoviruses, which have been shown to persist in the testes and other immune privileged sites. Sexual transmission of filoviruses was first reported in 1968 after an outbreak of Marburg virus disease and recently caused flare-ups of Ebola virus disease in the 2013-2016 outbreak. The team found that Marburg virus persists in seminiferous tubules and that Sertoli cells are the reservoir for the virus.

https://www.sciencedaily.com/releases/2018/08/180830180111.htm

Also:
https://www.cell.com/cell-host-microbe/fulltext/S1931-3128(18)30431-1?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS1931312818304311%3Fshowall%3Dtrue

threecents

Detecting Ebola RNA from tissues of monkeys that recovered from Ebola infection is junk science? How so?

gabrielshorn2013

So sorry that you think that epidemiology is junk science. It is what helped eradicate smallpox, and suppresses other diseases from becoming serious outbreaks. Knowing the route of transmission is critical in understanding why this deadly disease pops up. This particular disease is disastrous to the infected patient. You begin to bleed out through every orifice as your tissues liquefy. It is about 95% fatal. Understanding the disease allows prevention and possibly a cure.

sej58

I would say most of them do have pets.

jwhamann

I hope these scientists don’t have pets...

public-redux

How come?

threecents

JW, I hope you learn to give a &*%^ about the people who die from Ebola.

gabrielshorn2013

[thumbup]

jwhamann

Computer programming should be advanced by now to solve this rather than killing animals.

gabrielshorn2013

@jwhamann: Unfortunately, it is not. The only way to find out what tissues a pathogen lies dormant in is to examine those tissues. A computer modeling will not do that unless the programmers already understand the biology. This is especially true for viral pathogens. As I told Samantha above, this is critical to understanding the epidemiology of disease. Since the virus lies dormant in the testes of these animals, anything that eats the animal (even humans as "bushmeat") may be infected or allow transmission. It is important to understand why the virus lies dormant in the testes after recovery. What receptors are they? How does it cross the Sertoli boundary? Do other animals have the same or similar structure or receptors? The list goes on.

threecents

Sadly computer programs and even tissue culture cannot come close yet to controlling for all the variables involved in an infected person. Right now the best things we have are animal models, and wherever possible rodents are used, but monkeys are by far the best animal models.

gabrielshorn2013

Exactly three. Right now the only way to study these issues are with animal models.

Welcome to the discussion.

Keep it Clean. Please avoid obscene, vulgar, lewd, racist or sexually-oriented language.
PLEASE TURN OFF YOUR CAPS LOCK.
Don't Threaten. Threats of harming another person will not be tolerated.
Be Truthful. Don't knowingly lie about anyone or anything.
Be Nice. No racism, sexism or any sort of -ism that is degrading to another person.
Be Proactive. Use the 'Report' link on each comment to let us know of abusive posts.
Share with Us. We'd love to hear eyewitness accounts, the history behind an article.